| Pair Name | Eugenol, Sorafenib | ||
| Phytochemical Name | Eugenol (PubChem CID: 3314 ) | ||
| Anticancer drug Name | Sorafenib (PubChem CID: 216239 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Sorafenib |
| Adverse Reactions | Facial red macules, dry skin, acne, alveolitis. This was inferred hot nature anticancer drug. |
| Recommendations | Cold: Ilex hainanensis; Mangifera indica; Camellia sinensis; Sophora flavescens; Eriobotrya japonica; Citrus aurantium; |
| Reference | Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022. ref_link |
| Pair Name | Eugenol, Sorafenib | |||
| Disease Info | [ICD-11: 2D10.Z] | Thyroid cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Cleavage | CASP8 | hsa841 |
| Down-regulation | Cleavage | CASP9 | hsa842 | |
| In Vitro Model | 8305C | Thyroid gland anaplastic carcinoma | Homo sapiens (Human) | CVCL_1053 |
| Result | The most potent apoptotic effect was achieved with sorafenib and eugenol at their IC50. Lower doses of sorafenib could be used with eugenol to improve its efficacy while reducing its side effects. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Eugenol: A New Option in Combination Therapy with Sorafenib for the Treatment of Undifferentiated Thyroid Cancer. Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):313-321. doi: 10.18502/ijaai.v21i3.9804. | Click |
